A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

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The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).

Conditions:

Myocardial Infarction Coronary Microvascular Disease

Study Start (Actual) 2024-11

Primary Completion (Estimated) 2025-04

Study Completion (Estimated) 2025-04

Enrollment (Estimated) 52

Study Type OBSERVATIONAL

Phase N/A

Locations:

📍 Rochester, Minnesota, United States

Eligibility Criteria

Description

Inclusion Criteria:

* Ability to give informed consent
* Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease)
* For controls: atypical chest pain with indication for CMD testing
* For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value \>99th centile+ evidence of symptoms or signs of myocardial ischemia)

Exclusion Criteria:

* Acute coronary event (evidence of plaque rupture, fissure or dissection on coronary angiogram)
* Known to have angiographically significant CAD/pressure wire positive for epicardial CAD
* Inability to receive heparin products
* Allergy/contraindication to acetylcholine/adenosine/nitroglycerine products
* Prior coronary artery bypass grafting
* Pregnancy (if sexually active woman of reproductive age, need negative pregnancy test prior to proceeding with coronary angiography - this is standard of care in cath lab)
* Asthma with prior ICU admission due to bronchospasm/need for invasive ventilation

Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: No

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted2023-03-20
First Submitted that Met QC Criteria2023-03-30
First Posted2023-03-31

Study Record Updates

Last Update Submitted that Met QC Criteria2024-02-01
Last Update Posted2024-02-02
Last Verified2024-02