Assessment of the Ocular Microbiome in Health and Disease

RECRUITING

I'm interested ...!!

The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.

Conditions:

Microbial Colonization Eye Diseases Ophthalmopathy

Study Start (Actual) 2023-09-07

Primary Completion (Estimated) 2026-09-30

Study Completion (Estimated) 2026-12-30

Enrollment (Estimated) 500

Study Type OBSERVATIONAL

Phase N/A

Locations:

📍 Nashville, Tennessee, United States

Eligibility Criteria

Description

Inclusion Criteria:

We will include subjects who meet all of the following criteria:
* 18 years of age or older
* Provide informed consent
* Cohort A - normal eyes with no ocular disease
* Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
* Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
* Cohort D - Dry AMD (age related macular degeneration)
* Cohort E - Wet AMD
* Cohort F - diabetic retinopathy

Exclusion Criteria:

We will exclude subjects who meet all of the following criteria:
* Prior ocular disease either of the anterior or posterior segment
* Any medical comorbidities except well controlled DH and HTN
* Unable to follow up with study procedures as described

Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: Yes

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted2022-05-19
First Submitted that Met QC Criteria2022-06-07
First Posted2022-06-10

Study Record Updates

Last Update Submitted that Met QC Criteria2023-09-14
Last Update Posted2023-09-18
Last Verified2023-09