• Inclusion Criteria (Healthy Volunteers)
• 1. All volunteers must be 18 years of age or older, able to read, understand and voluntarily sign and informed consent document.
• 2. Volunteers must have no current medical history of brain disease
• 3. Negative pregnancy test if female of childbearing potential.
• 4. Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry for the duration of study participation.
• Inclusion Criteria (Alzheimer's Disease or ALS)
• 1. All volunteers must be 18 years of age or older, able to read, understand and voluntarily sign and informed consent document.
• 2. Subjects must have a diagnosis of Alzheimer's Disease or ALS for which they are under a physician's care.
• 3. Subjects must have a negative pregnancy test if female of childbearing potential
• 4. Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry for the duration of the study participation.

Exclusion Criteria:

• 1. Participants with evidence of brain disease other than ALS or Alzheimer's Disease at the time of enrolment up to agent administration are to be excluded from the study.
• 2. Concomitant medication use that, in the judgement of the investigator, would make the participant inappropriate for enrolment.
• 3. Severe concurrent disease, infection, or medical co-morbidity that, in the judgement of the investigator, would make the participant inappropriate for enrolment.
• 4. Participants who are receiving other investigational radiation drugs.
• 5. Women who are pregnant or breast feeding.
• 6. Subjects who are unable to tolerate PET/CT imaging